Main meta-analyses report
Primary direct replication, computational reproduction, sensitivity analyses, funnel plots, Egger regressions, and leave-one-out analyses.
Open reportProject overview
Replication of Reis et al. (2019)
This site brings together the main rendered outputs from a direct replication of a preclinical systematic review and meta-analysis on minocycline’s antidepressant-like effects in rodents.
The project was designed to assess how far the original review could be independently reconstructed from the published record, including study identification, quantitative synthesis, and risk-of-bias assessment.
To make the outputs easier to navigate, the materials are presented as two complementary reports: one focused on the main meta-analytic results and sensitivity analyses, and another focused on comparison of SYRCLE risk-of-bias judgements between the original review and the direct replication.
Available reports
Risk-of-bias report
Comparison of SYRCLE risk-of-bias judgements between the original review and the direct replication, including paired agreement analyses.
Open report